Journal of International Psychiatry

Abstract: Objective: To evaluate effect of risperidone and amisulpride Paley schizophrenia serum prolactin levels, body weight and cognitive function of first-episode medication of female spirit. Methods: 90 cases of female patients with schizophrenia can be divided into two groups: Mr. Pp ketone group 45 cases were treated by oral peary pp ketone zyban treatment, tolbutamide will benefit group of 45 patients with oral tolbutamide will the treatment, two groups of treatment for 12 weeks. Compare two groups of patients before and after the treatment the serum prolactin level, body quality and PANSS score, grade and MCCB WMS - RS.Results: Two groups of serum prolactin levels after treatment in each cycle than before treatment were significantly increased (P < 0.05), after treatment is similar between the two groups had no statistical significance (P > 0.05); Two groups before 12 weeks after treatment the body quality is treatment has significantly increased (P < 0.05), peary pp ketone group increase rate is lower than the tolbutamide will benefit group (P < 0.05); Two groups of PANSS score 12 weeks after treatment than before treatment had significantly lower (P < 0.05), but the pp ketone group was significantly lower after treatment than tolbutamide will benefit group (P < 0.05); 12 weeks after treatment, two groups of WMS - RS scores, MCCB score significantly higher than before treatment (P < 0.05), but Mr. Pp ketone group of WMS - RS score, MCCB score will increase significantly higher than that of tolbutamide, the group (P < 0.05).Conclusion: Paley risperidone and amisulpride can lead to serum prolactin and body weight were increased, but amisulpride body weight increased more sharply. The two drugs can significantly improve the cognitive impairment of schizophrenia, but risperidone treatment effect is better than that of Paley amisulpride.

[Key words] schizophrenia Risperidone; Paley; amisulpride; cognitive function