International Medical Research Frontier

Objective To systematically analyze the characteristics of adverse reactions and related risk factors of niacin for injection. Methods A total of 23,875 adverse reaction reports of nicotinic acid for injection included in the National Center for Adverse Drug Reaction Monitoring were extracted. Descriptive statistical methods were used to analyze the demographic characteristics of patients, drug-related situations, manifestations and outcomes of adverse reactions, and the independent risk factors for adverse reactions were identified through the logistic regression model. Results The results showed that the proportion of adverse reactions was higher in women, and middle-aged and elderly people were the high-risk groups. Adverse reactions mostly occur on the day of medication. Severe adverse reactions mainly involve the immune system, the whole body, the skin and its appendages. Off-label drug use, combined drug use, and non-standard solvent use are all important risk factors. Women are an independent risk factor for palpitations. Conclusion The adverse reactions of nicotinic acid for injection are closely related to the patient's age, gender, timing of medication, degree of medication standardization and combined medication. In clinical practice, it is necessary to strengthen the monitoring of special populations, strictly follow the instructions for medication, and standardize the operation to reduce risks.

Niacin for injection; Adverse reactions; Risk factors; Real-world research; Medication safety