International Medical Research Frontier

Objective To analyze the characteristics of adverse reactions and related risk factors of Ginkgo and Damo injection in the real world. Methods A total of 8,713 adverse reaction reports of Ginkgo Damo injection collected by the National Center for Adverse Drug Reaction Monitoring from January 1, 2019 to December 31, 2023 were extracted. Statistical analysis was conducted on the demographic characteristics, medication use, adverse reaction manifestations and outcomes of the patients. And verify the risk characteristics in combination with the results of literature retrieval. Results Among the adverse reaction reports, there were more females and more elderly patients aged 65 and above. 82.99% of adverse reactions occur on the day of medication, mainly involving the nervous system, skin and its appendages, and the digestive system. Severe adverse reactions are mainly immediate and often appear within a short period after medication. However, the overall prognosis is relatively good, and most patients can recover or improve after treatment. Conclusion The adverse reactions of Ginkgo and Damo injection are related to factors such as the patient's age, gender, timing of medication, and combined medication. In clinical practice, the use of drugs should strictly follow the instructions, strengthen the monitoring of special populations, and reduce the risk of medication.

Ginkgo and Damo Injection; Adverse reactions; Real-world research; Medication safety; Risk factors