Journal of International Psychiatry

【Abstract】 Objective To observe the effect of donepezil on learning and memory function and event- related potential in senile dementia. Methods 88 patients with senile dementia were selected and divided into observation group and control group according to the random number table, 44 cases in each group. The observation group was treated with donepezil and the control group was treated with Oaxitan.The simple mental state scale(MMSE) score, Barthel index (BI), event-related potential before and after treatment and the total incidence of adverse reactions were compared between two groups. Results The scores of orientation, memory, computing ability, memory ability and learning ability score and BI index were significantly higher in the observation group than those before treatment and the control group(P<0.05).The latency of Fz, C3 and C4 area in the observation group were lower than those before treatment and in the control group (P<0.05).The amplitude of Pz, C3 and C4 area in the observation group were higher than those before treatment and in the control group (P<0.05). The total incidence of adverse reactions were 13.64% and 11.36% in two groups, the difference was P>0.05. Conclusion Donapine treatment of senile dementia patients can effectively improve the learning and memory function and daily living ability, and Fz , C3 , C4 area latency shortened and Pz, C3, C4 area amplitude is more obvious, more conducive to promote cognitive function improve.

【Keywords】Senile dementia; Donepezil; Learning and memory; Event-related potentials