International Medical Research Frontier

Objective To explore the rationality analysis of clinical application of antibacterial drugs and the construction of drug resistance prevention and control system. Methods The medical records of 70 inpatients who used antibacterial drugs from January 2024 to December 2024 were retrospectively selected as the research object. According to the Guiding Principles of Clinical Application of Antibacterials, the rationality was evaluated from the aspects of drug indications, drug selection and drug administration scheme. At the same time, the results of pathogen culture and drug sensitivity test were collected, the drug resistance data were analyzed, and the construction of drug resistance prevention and control system was discussed. Results In 70 patients, the rational rate of antimicrobial use was 70.0% (49/70). The main reasons for the irrationality were unclear indications (57.1%) and improper drug selection (23.8%) (5/21). The positive rate of pathogen culture was 64.3% (45/70), and 52 strains of pathogens were isolated, of which 73.1% (38/52) were gram-negative bacteria. The resistance rate of Escherichia coli to fluoroquinolones was 66.7% (12/18), Klebsiella pneumoniae to cefotaxime was 66.7% (8/12), and Staphylococcus aureus to penicillin was 90.0% (7/8). Conclusion At present, the rationality of antimicrobial application needs to be improved, and the problem of drug resistance is prominent. It is necessary to build an effective drug resistance prevention and control system, which can effectively reduce the risk of drug resistance.

Antibacterials; Clinical rationality analysis; Construction of drug resistance prevention and control system