Hp感染对慢性胃炎患者血脂代谢特征的影响及危险因素分析-国际临床研究杂志-CSCIED科技核心评价数据库-手机版

Hp感染对慢性胃炎患者血脂代谢特征的影响及危险因素分析

The impact of helicobacter pylori infection on lipid metabolic profiles and analysis of risk factors in patients with chronic gastritis

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DOI	10.12208/j.ijcr.20250417
刊名	国际临床研究杂志 International Journal of Clinical Research
年，卷(期)	2025, 9(9)
作者	李心怡¹, 刘佩¹, 杨涓³, 曾雪丽¹, 张顺玲¹, 郑盛²,
作者单位	1 大理大学临床医学院云南大理 2 大理大学第二附属医院（云南省第三人民医院）云南昆明 3 云南大学附属医院云南昆明
摘要	目的探讨Hp阳性慢性胃炎患者血脂指标的变化情况，分析影响Hp阳性慢性胃炎患者的危险因素。方法本文回顾性分析了云南省第三人民医院2024年01月至2025年01月诊断的120例慢性胃炎患者，根据是否合并幽门螺杆菌（Hp）感染，分为Hp阳性组（55例）与Hp阴性组（65例）。研究比较两组患者的血脂代谢指标差异，并通过多因素logistic回归分析筛选出独立危险因素。结果性别、TC、TG、HDL、LDL、APO-A1、TC/HDL、TG/HDL、LDL/HDL在两组差异有统计学意义（P＜0.05）；多因素逻辑回归分析得出，性别（OR=0.335，95%CI：0.129～0.871）、TG（OR=0.505，95%CI：0.288～0.885）、HDL（OR=6.174，95%CI：1.831～20.814）、LDL（OR=0.409，95%CI：0.215～0.780）、TC/HDL（OR=1.444，95%CI：1.125～1.855）是Hp阳性慢性胃炎患者的独立危险因素，差异有统计学意义（P＜0.05）。结论 Hp阳性慢性胃炎患者可出现血脂代谢异常，早期根除Hp可改善血脂代谢异常，降低远期并发症的风险。
Abstract	Objective To investigate alterations in serum lipid profiles among patients with Helicobacter pylori (Hp)-positive chronic gastritis and to identify independent risk factors associated with Hp-positive disease. Methods A retrospective analysis was conducted on 120 patients diagnosed with chronic gastritis at the Third People’s Hospital of Yunnan Province between January 2024 and January 2025. Subjects were divided into an Hp-positive group (n = 55) and an Hp-negative group (n = 65) according to Hp infection status. Differences in lipid-metabolism indices between the two groups were compared, and multivariate logistic regression was applied to screen for independent risk factor. Results Sex, total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL), apolipoprotein A1 (APO-A1), TC/HDL, TG/HDL, and LDL/HDL differed significantly between groups (P < 0.05). Multivariate logistic regression identified sex (OR = 0.335, 95% CI: 0.129–0.871), TG (OR = 0.505, 95% CI: 0.288–0.885), HDL (OR = 6.174, 95% CI: 1.831–20.814), LDL (OR = 0.409, 95% CI: 0.215–0.780), and TC/HDL ratio (OR = 1.444, 95% CI: 1.125–1.855) as independent risk factors for Hp-positive chronic gastritis (P < 0.05). Conclusion Hp-positive chronic gastritis is accompanied by dyslipidemia. Early Hp eradication may improve lipid-metabolism disturbances and reduce the risk of long-term complications.
关键词	慢性胃炎；幽门螺杆菌；甘油三酯；胆固醇；危险因素
KeyWord	Chronic gastritis; Helicobacter pylori; Triglycerides; Cholesterol; Risk factors
基金项目
页码	23-27

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引用本文

李心怡, 刘佩, 杨涓, 曾雪丽, 张顺玲, 郑盛. Hp感染对慢性胃炎患者血脂代谢特征的影响及危险因素分析 [J]. 国际临床研究杂志. 2025; 9; (9). 23 - 27.

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