| Abstract |
Abstract: Objective: To comparison of plasma concentration and efficacy of buspirone and Vin Rafa Sin in patients with generalized anxiety disorder. Methods: From June 2013 to June 2016, 100 cases of generalized anxiety disorder patients were studied. According to the simple random method were divided into Buspirone group and Venlafaxine group. The relationship between HAMA, HAMD and SAS score of two groups, the relationship between the dosage and the concentration of the drug and the therapeutic effect were compared between the two groups. Results: The HAMA, HAMD and SAS scores of the two groups were decreased after treatment (P<0.05), and the HAMA, HAMD and SAS scores of venlafaxine group were lower than those of buspirone group (P<0.05) at the end of the 2 week, the 4 week and the third week after treatment. There was no significant correlation between serum concentration and HAMA score (r=0.575, p>0.05), and there was no significant correlation between p>0.05 and HAMA score (r=-0.175). There was no significant correlation between the serum concentration of venlafaxine group and HAMA score (r=0.582, p>0.05), and there was no significant correlation between the p>0.05 and the HAMA score (r=-0.164). The effective rate of buspirone group was 90%, the effective rate of venlafaxine group was 94%, and there was no significant difference between the two groups (p>0.05). Two groups of patients after treatment of anxiety and somatic anxiety spirit was lower than that before treatment (p<0.05); venlafaxine group after treatment in patients with mental anxiety score was significantly lower than that of buspirone group (p<0.05); venlafaxine group after treatment in patients with somatic anxiety score was significantly lower than that of buspirone group (p<0.05). Buspirone group of patients with 17 cases of adverse reactions, the incidence rate was 34%, patients with venlafaxine group with 13 cases of adverse reactions, the incidence rate was 26%, two groups of patients after treatment, the incidence of adverse reactions was no significant difference (P>0.05). Conclusion: Venlafaxine and buspirone in the treatment of generalized anxiety disorder have a better therapeutic effect, adverse reactions are lower, but the effect of venlafaxine is better than that of buspirone.
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