文拉法辛缓释剂联合综合心理干预治疗产后抑郁症的临床疗效

Clinical efficacy of venlafaxine combined with psychological intervention in the treatment of postpartum depression

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DOI
刊名
Journal of International Psychiatry
年,卷(期) 2018, 45(4)
作者
作者单位

泰州市妇幼保健所 ;
泰州市中医院妇产科 ;
泰州市第四人民医院精神科 ;

摘要
摘要:目的:探讨文拉法辛缓释剂联合综合心理干预治疗产后抑郁症的临床疗效。方法:选取2015年3月~2017年3月我院收治的产后抑郁症患者160例,按随机数字法分为观察组和对照组,各80例。对照组给予文拉法辛缓释剂,观察组在对照组的基础上给予综合心理干预治疗。采用抑郁自评量表(SDS)、焦虑自评量表(SAS)和症状自评量表(SCL-90)评估患者焦虑抑郁及临床症状情况。观察比较两组患者临床疗效,治疗前后SDS、SAS及SCL-90值的变化。结果:观察组临床总有效率为93.75%优于对照组(73.75%),差异有统计学意义(P<0.01);治疗后,两组患者SAS、SDS评分均较治疗前降低,且观察组患者SAS、SDS评分降低幅度较对照组大,差异有统计学意义(P<0.001);治疗后,两组SCL-90量表包含的10方面因子的分值均较治疗前降低,且观察组SCL-90量表包含的10方面因子的分值降低幅度较对照组大,差异有统计学意义(P<0.001);观察组治疗总依从率为91.25%优于(62.50%),差异有统计学意义(P<0.01)。结论:文拉法辛缓释剂联合综合心理干预治疗产后抑郁症患者,临床疗效确切,能有效的改善患者的焦虑抑郁状态,提高患者的治疗依从性。
Abstract
【Abstract】Objective: To investigate the clinical efficacy of venlafaxine combined with psychological intervention in the treatment of postpartum depression.Methods: 160 cases of postpartum depression in our hospital from March 2015 to March 2017 were randomly divided into observation group and control group, each with 80 cases. The control group was given venlafaxine sustained release agent, while the observation group was given comprehensive psychological intervention on the basis of the control group. The self rating Anxiety Scale (SDS), self rating Anxiety Scale (SAS) and symptom checklist 90 (SCL-90) were used to evaluate the anxiety, depression and clinical symptoms of the patients. The clinical efficacy of the two groups were observed and compared, and the changes of SDS, SAS and SCL-90 before and after treatment were observed.Results: the total efficiency of the observation group was better than the control group 93.75% (73.75%), the difference was statistically significant (P<0.01); after treatment, two groups of patients with SAS, lower SDS score than before treatment, and the patients in the observation group SAS and SDS were lower significantly than the control group, the difference was statistically significant (P<0.001) after treatment, the two groups decreased; SCL-90 scale contains 10 factors scores than before treatment, and the observation group SCL-90 included 10 factors scores decreased significantly than the control group, the difference was statistically significant (P<0.001); the observation group the total compliance rate was 91.25% (62.50%), is better than statistically significant difference (P<0.01).Conclusion: venlafaxine combined with psychological intervention in the treatment of patients with postpartum depression, the clinical curative effect is accurate, can effectively improve the patients anxiety and depression, improve the treatment compliance of patients.
关键词
关键词:产后抑郁症;综合心理干预;文拉法辛缓释剂
KeyWord
【Keyword】Postpartum depression;Comprehensive psychological intervention;Venlafaxine sustained release.
基金项目
页码 729-731
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顾颖华*,刘琴,陈振林,杨立夏. 文拉法辛缓释剂联合综合心理干预治疗产后抑郁症的临床疗效 [J]. 国际精神病学杂志. 2018; 45; (4). 729 - 731.

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