| Abstract |
【Abstract】 Objective: To study the small dose quetiapine flat joint ziprasidone for women the curative effect of patients with schizophrenia and body quality, serum prolactin level effect. Methods: From June 2014 to July 2016, 84 patients with schizophrenia in our hospital were randomly divided into observation group and control group, 42 cases in each group. The control group were treated with ziprasidone treatment, the observation group was treated with a small dose of quetiapine combined with ziprasidone treatment, compared before and after treatment of positive and negative symptom scale (PANSS), Clinical Global Impression Scale (CGI) and Treatment Emergent Symptom Scale (TESS) and the changes of. Results: the total effective rate of the observation group was 92.86% (39/42), significantly higher than that of the control group (32/42), the difference was statistically significant (P < 0.05). After treatment, the two groups of PANSS score and CGI score were significantly lower than before treatment, while the observation group was significantly lower than the control group, the differences were statistically significant (both P < 0.05). There was no significant difference in TESS scores between the two groups before treatment, and there was no significant difference in TESS scores between the two groups after treatment (mean P>0.05). There was no significant difference in the two groups before and after treatment, and the difference was statistically significant (both P < 0.05), the difference was statistically significant after treatment. The two groups before treatment, body weight and prolactin were no significant difference (P>0.05), body weight, lactation after treatment two groups of patients were significantly higher than those before treatment (P<0.05), two groups of body weight and prolactin had no significant difference (P>0.05). Conclusion: A small dose of quetiapine combined with ziprasidone in the treatment of female schizophrenia in improving the clinical curative effect, but it can cause serum prolactin and body weight increased, should give effective intervention to avoid elevated prolactin.
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