| Abstract |
Abstract Objective: To study psychological stress and ineuro-immune of patients with aparoscopic cholecystectomy and cholangiocarcinoma surgery. Method: 90 cases of patients who received cholecystectomy in pour hospital since May 2014 to August 2016 were selected as the object of study and were divided into laparoscope group and laparotomy group as per laparoscopic cholecystectomy and Cholangiocarcinoma surgery. Patients were provided with HAMA anxiety scale for evaluating variations in anxiety symptoms before and after surgery. What’s more, they were compared for severity of anxiety symptoms before surgery and level of related immune globulin on the day of admission and the day of surgery, and were examined for systolic pressure, diastolic pressure and pulse rate. Results: According to HAMA anxiety scale, the insomnia, fear, tonus, attention, dysmnesia, anxious mood, depressive mood and total scores before surgery of both groups were higher than those after surgery, with statistical significance (t=24.400，t=24.112，t=28.842，t=26.393，t =28.942，t=39.362，t=18.346，P<0.001). Insomnia, fear, tonus, anxious mood, depressive mood and total sores of laparoscope group before surgery were higher than those in laparotomy group, having statistical significance (t=33.693，t=28.455，t=33.693，t=33.693，t=33.693，t=33.693，t=33.693，P<0.001). IgM, IgG and IgA of patients in laparoscope group on the day of admission were significantly higher than those on the day of surgery, having statistical significance (t=5.488，t=8.591，t=3.671，P<0.001), and the IgM, IgG and IgA of patients in laparotomy group on the day of admission were significantly higher than those on the day of surgery, having statistical significance (t =6.791 ，P<0.001，t =7.027，P<0.001，t =2.566，P =0.012), while there was no distinct difference in comparison between two groups (P>0.05). There was significance difference in systolic pressure, diastolic pressure and pulse rate of patients in laparoscope group between the day of admission and the day of surgery, having statistical significance (t =2.726，P=0.007，t =3.757、t =16.302，P<0.001), and significant difference in systolic pressure, diastolic pressure and pulse rate of patients in laparotomy group between the day of admission and the day of surgery, having statistical significance (t =2.990，P=0.004，t =4.745、t =19.066，P<0.001), while there was no distinct difference in comparison between two groups (P>0.05). Conclusion: There is serious psychological stress of surgical patients before surgery, which appears as anxious mood that can be dramatically relieved after surgery due to relief of pain. Moreover, preoperative psychological stress of major surgery was lower than that of minimally invasive surgery. Humoral immune function of surgical patients decreased due to psychological stress, which can influence physical signs.
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