Contemporary Nursing

Objective To investigate the mechanism by which bacterial vaginosis (BV) synergizes with persistent human papillomavirus (HPV) infection in promoting cervical lesions and to study corresponding nursing intervention strategies. Methods A total of 368 patients with cervical lesions admitted to our hospital from August 2023 to August 2025 were selected as the observation group, while a healthy population during the same period was chosen as the comparison group. The correlation regarding the mechanism of BV synergizing with persistent HPV infection in promoting cervical lesions was explored. Based on the mechanistic correlation, the observation group was further divided into a control group (receiving routine care) and an experimental group (receiving comprehensive care), with 184 cases in each group. The improvements in symptoms (relief rate of abnormal vaginal discharge, HPV clearance rate, relief rate of cervical lesions), quality of life, and nursing satisfaction were compared between the two groups. Results The observation group had higher rates of BV positivity and persistent HPV infection. Co-infection with BV and HPV was more likely to lead to CIN III or higher-grade lesions. All three factors were identified as independent risk factors for cervical lesions. After nursing interventions, the experimental group showed significantly higher rates of relief for abnormal vaginal discharge, HPV clearance, and cervical lesion relief compared to the control group. Scores for quality of life and nursing satisfaction were also significantly higher in the experimental group, with statistical significance. Conclusion Bacterial vaginosis synergizes with persistent HPV infection to promote cervical lesions by disrupting the vaginal microecology, damaging the cervical mucosa, and activating immune-inflammatory responses. Comprehensive nursing interventions can effectively improve clinical symptoms, thereby enhancing patients' quality of life and satisfaction.

Bacterial vaginosis; Persistent HPV infection; Cervical lesions; Mechanism analysis; Nursing intervention