认知康复训练对难治性癫痫患者认知功能改善的对照研究
Effects of cognitive rehabilitation for refractory epilepsy patients with cognitive dysfunction: a pilot randomized controlled trial
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| DOI |
| 刊名 |
Journal of International Psychiatry
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| 年，卷(期) |
2018, 45(5) |
| 作者 |
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| 作者单位 |
江苏省常州102医院 ;
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| 摘要 |
目的：观察对难治性癫痫病伴认知功能障碍患者进行认知功能康复训练的效果，及Addenbrooke认知评估量表（ACE-III）使用情况。方法：择取本院收治的115例难治性癫痫伴认知功能障碍患者为研究对象，采用随机数字表法将患者分成两组: 对照组57例，给予常规抗癫痫药物治疗; 观察组58例，在对照组治疗的基础上增加以智能软件辅助的记忆力强化训练、运动锻炼和认知刺激训练结合的康复训练。8周后用ACE-III对两组患者认知功能障碍情况进行治疗前后的差异比较。结果：对照组治疗前后无论是注意、记忆力、语言流利性、语言和视空间的各领域评分，还是总评分，数据变化均无临床意义（P>0.05）；而观察组治疗后总评分和记忆力比治疗前提升显著（P<0.001），注意、语言和视空间领域评分也明显提高（P<0.05）；观察组和对照组治疗后比较结果，与观察组本身在治疗前后的结果类似。ACE-III应用灵活便利，依从性高。结论：在对难治性癫痫病认知功能障碍患者常规治疗的同时加强认知功能康复训练，可有效改善患者的认知功能情况。ACE-III作为新的评估认知的工具，应用效果好值得推广。
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| Abstract |
Objective: To evaluate the effects of cognitive rehabilitation for refractory epilepsy patients with cognitive dysfunction , and observe the results of application of Addenbrooke’s Cognitive Examination （ACE-III）.Methods: 115 refractory epilepsy patients with cognitive dysfunction in our hospital were randomly divided into the control group and the observation group: 57 cases in the control group that were given conventional therapy with antiepileptic drug; 58 cases in the observation group that were given conventional therapy and cognitive rehabilitation therapy that was combined by memory training aided by electronic software, physical exercise and cognitive irritation training. After 8 weeks, all patients were assessed by ACE-III to evaluate the change of the cognitive dysfunction between before treatment and after treatment. Results: In the control group, there was no significant difference between before treatment and after treatment in the total ACE-III score and the score in attention, memory, verbal fluency, language and visuospatial abilities（P>0.05）; Nevertheless, in the observation group, the total ACE-III score and the score in memory after treatment were significantly higher than before treatment（P<0.001）. Also, the score of attention, language and visuospatial after treatment were higher than before treatment（P<0.05）; the results between the control group and the observation group after treatment were similar with the results between before treatment and after treatment of the observation group. ACE-III was flexible and convenient for use, and its patient compliance was high. Conclusion: Conventional therapy combined with cognitive rehabilitation significantly improve the degree of cognitive dysfunction in epilepsy patients. ACE-III as a new tool of cognitive examination is worth popularizing.
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| 关键词 |
难治性癫痫病；认知功能障碍；Addenbrooke认知评估量表 ACE-III
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| KeyWord |
intractable epilepsy; cognitive impairment; Addenbrooke cognitive assessment scale; ACE-III
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| 基金项目 |
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| 页码 |
904-906 |
蒋建波*.
认知康复训练对难治性癫痫患者认知功能改善的对照研究 [J].
国际精神病学杂志.
2018; 45; (5).
904 - 906.