Journal of International Psychiatry

【Abstract】Objective To study the effect of different doses of venlafaxine on the prognosis of patients with acute anxiety disorder after stroke. Method 86 patients with acute anxiety in our hospital were selected as the subjects. The patients were randomly divided into observation group and control group. Two groups were given routine drug in the treatment of stroke. The observation group was given a large dose of venlafaxine 150mg/d, while the control group was treated with small dose of 75mg/d for 8 weeks. All the patients were treated for 1 courses with 8 weeks. The two groups of Hamilton Anxiety Scale (HAMA) score, the National Institutes of Health Stroke Scale (NIHSS) score, the daily living ability scale (ADL) score and the incidence of adverse reactions were recorded. Result After treatment, the scores of somatization, anxiety and HAMA in the observation group were lower than those before treatment (P<0.05). After treatment for 2 weeks, the scores of the control group were lower than those before treatment (P<0.05). The observation group was significantly lower than the control group at the end of 1 and 2 weeks (P<0.05). Compared with before treatment, NIHSS and ADL scores of the two groups after treatment were significantly improved (P<0.05). The NIHSS score of the observation group was lower than that of the control group after treatment, and the ADL score was higher than that of the control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion Different doses of venlafaxine in the treatment of acute post-stroke anxiety disorder can significantly improve the patients stroke, anxiety symptoms, but the effect of large dose improvement is more obvious and faster onse. Large dose adverse reactions did not increase significantly and it has better application prospect.

【Keywords】Different dosage, Venlafaxine, Stroke, Acute anxiety disorder, Prognosis