International Journal of Nursing Research

Chronic Liver Disease (CLD) is a major global public health issue. It has a long course and many complications, seriously affecting the quality of life of patients. Pruritus is one of the most common and painful complications of chronic liver diseases, especially in cholestatic liver diseases such as primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC). Cholestatic pruritus has a complex mechanism and varies in severity, ranging from mild discomfort to unbearable and stubborn itching. It often leads to sleep deprivation, anxiety and depression, inattention, and even suicidal tendencies in patients, thereby greatly damaging their quality of life. This article aims to systematically review relevant literature, summarize the pathophysiological mechanism of chronic liver disease complicated with pruritus, its multi-dimensional impact on quality of life, and focus on discussing the currently effective nursing intervention measures. The article divides nursing intervention into two major categories: non-pharmacological nursing intervention (such as skin care, environmental regulation, psychological support, health education and empowerment) and the nursing cooperation and management of pharmacological treatment. It emphasizes the core value of the patient-centered, individualized and full-process nursing model in alleviating patients' suffering and improving their quality of life. Finally, this paper looks forward to future research directions, such as the nursing application of new treatment methods and digital health intervention, with the aim of providing theoretical basis and practical guidance for clinical nursing practice.

Chronic liver disease; Cholestatic pruritus; Quality of life; Nursing intervention; Symptom management; Review