Journal of International Psychiatry

【Abstract】 Objective To investigate the clinical efficacy of paroxetine combined with duloxetine in the treatment of depression with somatization disorder. Methods Thirty patients with depression and somatosensory disorder were enrolled in the SCL-90 and Znug Depression Self-Rating Scale (SDS). The patients were randomly divided into treatment group and control group (n = 15) Given oral paroxetine + duloxetine and oral duloxetine treatment, 4 weeks for a course of treatment. The patients SCL-9 and SDS scores were measured before and 4 weeks after treatment. Results There was no significant difference in SCL-9 and SDS scores between the two groups before treatment (P> 0.05). ② After 4 weeks of treatment, the SDS score of the treatment group was lower than that of the control group, the difference was statistically significant (P <0 (P <0.05). (3) After treatment for 4 weeks, the SCL-9 score of the treatment group was lower than that of the control group, the difference was statistically significant (P <0.05), and the difference was statistically significant (P <0.05). The scores of SCL-9 in the two groups were lower than those before treatment (P <0.05). Conclusion Paroxetine combined with duloxetine can improve the depression and somatization disorder, which is worthy of clinical application.

【Key words】 Paroxetine; Duloxetine; Depression; Somatization disorder