Journal of International Psychiatry

[Abstract] ObjectiveTo investigate the changes of liver function, lipid metabolism and liver ultrasound in patients with chronic viral hepatitis B complicated with schizophrenia.Methods 36 cases of patients with chronic viral hepatitis B complicated with schizophreniatreated in our hospital duringFebruary 2015 to January 2017(study group) and 30 cases of patients with simple chronic viral hepatitis B who were admitted to our hospital over the same period (control group) were enrolled in the study. Routine and ultrasonic examinations were performed in the two groups after admission. The liver function [alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBiL)], indexes of lipid metabolism [triglyceride (TG), serum total cholesterol (TC), low-density lipoprotein (LDLC), high-density lipoprotein (HDLC)] and changes of liver ultrasound were compared between the two groups. Results The levels of ALT, AST and TBiL in the study group were significantly higher than those in the control group(P< 0.05). The levels of TG, TC and LDLC were significantly higher, while HDLC level was significantly lower in the study group than in the control group (P< 0.05). The changes of liver ultrasound showed that the probabilities of liver edge passivation, liver parenchyma with inhomogeneous echo and the largest oblique diameter of right liver lobe increasing in the study group were significantly higher than those in the control group(P< 0.05).Conclusion Patients with chronic viral hepatitis B complicated with schizophrenia has significantly decreased liver function, lipid metabolism and liver ultrasound changes, and schizophrenia may exacerbate the progression of chronic viral hepatitis B, which provides bases for carrying out reasonable prevention measures.

[Keywords]Chronic viral hepatitis B; Schizophrenia; Liver function; Lipid metabolism; Liver ultrasound