Journal of International Psychiatry

[Abstract] Objective: To investigate the effects of amisulpride in first-episode schizophrenia patients and the clinical effect on blood lipids, thyroid hormone levels. Methods: 70 patients with first-episode schizophrenia were treated from January 2014 to December -2016 in the hospital. The patients were randomly divided into control group (n=35) and observation group (n=35). The control group were given risperidone treatment, observation group were treated with amisulpride treatment by chemiluminescence immunoassay in 2 groups before and after treatment of thyroid hormone levels, 2 groups of patients before and after treatment, blood lipid levels were measured by automatic biochemical analyzer, and compared 2 groups of clinical curative effects on blood lipids and thyroid hormone levels. Results: the observation group after 8 week of treatment, clinical curative rate was 94.29%, and 91.43% in the control group had no significant difference (P>0.05); no significant differences in lipid levels in the 2 groups before treatment (P>0.05); the observation group 8 weeks after treatment of TC, TG, HDL and LDL levels lower than the control group (P< 0.05); comparison of thyroid hormone levels have no significant difference between the 2 groups before treatment (P>0.05); the observation group 8 weeks after treatment of T3, T4, FT3, FT4 levels lower than the control group (P<0.05); the observation group before and after treatment, the thyroid hormone levels had no significant difference (P>0.05); the observation group after 8 weeks of treatment the level of TSH that is higher than the control group (P<0.05). Conclusion: Patients with first-episode schizophrenia with risperidone and amisulpride is as effective, but amisulpride effects on blood lipid and thyroid hormone levels in small, high safety, and is worthy of popularization and application.

[Key words] amisulpride; schizophrenia; clinical effect; blood lipid; thyroid hormone; Risperidone; safety