| Abstract |
Abstract: Objective To investigate the relationship between serum brain derived neurotrophic factor, cytokine and cognitive function in first-episode schizophrenia. Methods A total of 82 cases of schizophrenia patients were selected as the first group, 80 patients of discontinued >30d recurrence of schizophrenia were selected as relapse group and 80 cases of healthy families volunteers were selected as control group in our hospital from January 2015 to January 2017. Serum brain-derived neurotrophic factor (BDNF), serum adiponectin (APN), hormone binding protein (SHBG), leptin (LEP), retinol binding protein 4 (RBP4) and cognitive function were measured and compared between the 3 groups. To analyze the association of BDNF with fat cell factor and cognitive function in first-episode schizophrenia. Results The serum levels of BNDF and APN in the group first and the relapse group were significantly lower than those in the control group (P<0.05), and the levels of LEP, SHBG and RBP4 were significantly higher than those of the control group (P<0.05). The scores of serum WMS-IV and WAIS-IV in the first group and the relapse group were significantly lower than that in the control group (P<0.05), and there was no significant difference between the first group and the relapse group (P>0.05). The first serum BNDF levels of schizophrenia patients with APN showed positive correlation (P<0.05), and LEP, SHBG and RBP4 showed a negative correlation (P<0.05), schizophrenia serum BNDF level in patients with language and auditory memory, visual memory, visual working memory, immediate memory, immediate memory, delayed memory, delayed memory, language understanding, reasoning, working memory, processing speed, cognitive efficiency showed positive correlation (P<0.05). Conclusion Serum BNDF levels can affect serum lipid levels and cognitive function in patients with first-episode schizophrenia, and low expression of BNDF may be a risk factor for relapse in first-episode schizophrenia or schizophrenia.
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