Journal of International Psychiatry

【Abstract】Objective To investigate the efficacy of escitalopram oxalate in the treatment of post stroke depression(PSD) and its influence on MMSE scores and ADL scores. Methods 120 case of PSD were divided into an control group(60 cases) and an observation group(60 cases) randomly, and control group was given Shugan Jieyu capsules baesd on conventional therapy, while observation group received escitalopram oxalate based on conventional therapy,and the efficacy was evaluated by NIHSS, HAMD, MMSE and ADL. Results The comparison of these scale scores among different time points within the groups showed that the NIHSS scores, HAMD scores, MMSE scores and ADL scores within the observation group and control group had obvious differences among before treatment, 4 weeks after treatment and 24 weeks after treatment(P＜0.05) .The comparison of these scale scores between the 2 groups at different time points showed that there were no obvious differences in these scale scores between the 2 groups before treatment (P＞0.05), while the HAMD scores of observation group were obviously lower than those of control group (P＜0.05), and no obvious differences were found in other scale scores between the 2 groups 4 weeks after treatment(P＞0.05), moreover, the NIHSS scores and HAMD scores of observation group were obviously lower than those of control group(P＜0.05), while the MMSE scores and ADL scores of observation group were obviously higher 24 weeks after treatment(P＜0.05). Conclusion The escitalopram oxalate in the treatment of PSD shows good efficacy, which has some advantages such as promoting neurological function recovery, relieving depressive symptoms, improving cognitive dysfunction and activities of daily living.

【key words】 Escitalopram oxalate; Post stroke depression; Cognitive dysfunction; Activities of daily living