检测炎性因子(IL-6、TNF-a)、皮质醇及5-羟色胺(5-HT)对临床评价抑郁症患者病情发展及预后的作用-国际精神病学杂志-CSCIED科技核心评价数据库-手机版

检测炎性因子(IL-6、TNF-a)、皮质醇及5-羟色胺(5-HT)对临床评价抑郁症患者病情发展及预后的作用

Objective to investigate the role of inflammatory factors (IL-6, TNF-a), cortisol and 5- serotonin (5-HT) in the clinical evaluation of the development and prognosis of patients with depression

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DOI
刊名	国际精神病学杂志 Journal of International Psychiatry
年，卷(期)	2018, 45(6)
作者	王西田*,王淑红,张陕宁,赵珊,张晓博,
作者单位	陕西省宝鸡市康复医院检验科 ; 宝鸡市人民医院 ;
摘要	摘要：探讨检测抑郁症患者炎性因子和皮质醇及5-羟色胺(5-HT)对其病情及预后的评价作用。方法选取医院收治的76例抑郁症患者作为本次研究观察组，另选取医院76例同期入院健康体检的正常健康者为对照组。分别检测两组受检对象炎性因子(IL-6、TNF-α)、皮质醇和5-羟色胺(5-HT)水平，采用汉密尔顿抑郁表(HAMD)评分其抑郁症状，并分析患者病情程度与其临床各项指标间的相关性。结果观察组患者IL-6、TNF-α、皮质醇及5-HT水平分别为(6.81±2.18) ng/L、(7.61±2.52) ng/L、(134.88±44.75) ug/L、(22.54±6.98) ug/L与对照组(1.49±0.51) ng/L、(2.38±0.71) ng/L、(73.65±21.69) ug/L、(45.71±7.62) ug/L，t=(20.71，17.41，10.73，19.54)，P=(0.00，0.00，0.00，0.00)；随着抑郁症患者病情的增加，其IL-6、TNF-α、皮质醇水平明显升高，而5-HT水平不断下降，P<0.05。结论检测抑郁症患者炎性因子和皮质醇及5-HT水平可有助于评价其病情及预后，为临床治疗方案制定及预后判断提供参考。
Abstract	Abstract：objective To investigate the effect of inflammatory factors and cortisol and serotonin (5-HT) on the prognosis and prognosis of patients with depression.Methods 76 patients with depression were selected as the study group, and 76 normal hospital healthy subjects were selected as the control group. The levels of IL-6, TNF-α, cortisol and serotonin (5-HT) were measured in the two groups. The depressive symptoms were scored by Hamilton Depression Table (HAMD) and the severity of the patients was analyzed. The correlation between clinical indicators.Results The levels of IL-6, TNF-α, cortisol and 5-HT in the observation group were (6.81±2.18) ng/L、(7.61±2.52) ng/L、(134.88±44.75) ug/L、(22.54±6.98) ug/LVS(1.49±0.51) ng/L、(2.38±0.71) ng/L、(73.65±21.69) ug/L、(45.71±7.62) ug/L，t=(20.71，17.41，10.73，19.54)，P=(0.00，0.00，0.00，0.00). The levels of IL-6, TNF-α and cortisol were significantly increased with the increase of the condition of depressive patients, while the levels of 5-HT were decreased , P<0.05.Conclusion The detection of inflammatory factors, cortisol and 5-HT levels in patients with depression can help to evaluate the disease and prognosis, and provide a reference for clinical treatment and prognosis.
关键词	关键词：皮质醇；炎性因子；5-羟色胺；抑郁症；预后
KeyWord	Keywords：Cortisol;Inflammatory factor;Serotonin;Depression;Prognosis
基金项目
页码	1032-1034

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王西田*,王淑红,张陕宁,赵珊,张晓博. 检测炎性因子(IL-6、TNF-a)、皮质醇及5-羟色胺(5-HT)对临床评价抑郁症患者病情发展及预后的作用 [J]. 国际精神病学杂志. 2018; 45; (6). 1032 - 1034.

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