无抽搐电休克在儿童精神分裂患者中的临床效果及对认知功能的影响研究

The clinical efficacy of modified electroconvulsive therapy in children with schizophrenia and its influence on cognitive function

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DOI
刊名
Journal of International Psychiatry
年,卷(期) 2018, 45(4)
作者
作者单位

首都医科大学附属北京安定医院 ;
首都医科大学附属北京安定医院儿科 ;

摘要
【摘要】目的:探讨无抽搐电休克在儿童精神分裂症患者中的临床效果及对认知功能的影响。方法:取2015年3月-2017年4月医院收治的儿童精神分裂症患者90例,随机数字法分为对照组(n=45)和观察组(n=45)。对照组采用利培酮治疗,观察组采用无抽搐电休克治疗,采用阳性与阴性症状量表(PANSS)量表对患者治疗前、后症状进行评估;采用事件相关电位测试剂及眼动测定2组治疗前、后认知功能情况,比较2组临床疗效及对认知功能的影响。结果:观察组效率为97.78%与对照组84.44%比较差异有统计学意义(P<0.05);2组治疗前PANSS量表评分比较差异无统计学意义(P>0.05);观察组治疗后1个月、2个月及3个月PANSS量表评分,均低于对照组(P<0.05);2组治疗前电位P300的潜伏期和波幅及眼动测定水平比较差异无统计学意义(P>0.05);观察组治疗后电位P300的潜伏期和波幅,高于对照组(P<0.05);观察组治疗后眼动测定水平,均高于对照组(P<0.05)。结论:儿童精神分裂症患者采用无抽搐电休克治疗效果理想,有助于改善患者认知功能,值得推广应用。
Abstract
Abstract: Objective: To investigate the clinical effect of modified electroconvulsive therapy (ECT) in children with schizophrenia and its influence on cognitive function. Methods: 90 children with schizophrenia in our hospital from March 2015 to April -2017 were randomly divided into two groups: the control group (n=45) and the observation group (n=45). The control group were given risperidone treatment, observation group were treated with modified electroconvulsive therapy, with positive and negative symptoms scale (PANSS) scale to assess the patients before and after treatment of symptoms; cognitive function in 2 groups before and after treatment were measured by event-related potentials test and eye movement, compared 2 groups of clinical curative effect and influence on cognitive function. Results: the observation group efficiency was 97.78% and 84.44% in the control group the difference was statistically significant (P<0.05); the 2 groups before treatment PANSS score had no significant difference (P>0.05); the observation group after treatment for 1 months, 2 months and 3 months PANSS score were lower than the control group (P<0.05) the 2 groups before treatment; the latency and amplitude and eye movement potentials P300 level determination of no significant difference (P>0.05); the latency and amplitude of potential P300 patients in the observation group, higher than that of the control group (P<0.05); the observation group after the treatment of eye level determination, were higher than the control group (P<0.05). Conclusion: the use of modified electroconvulsive therapy in children with schizophrenia is ideal and helpful to improve the cognitive function of the patients. It is worth popularizing.
关键词
【关键词】儿童精神分裂症;无抽搐电休克;利培酮;认知功能
KeyWord
Keywords children; schizophrenia; modified electroconvulsive therapy; Risperidone; cognitive function
基金项目
页码 632-634
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李斌,戚艳杰,张之霞,郑毅*. 无抽搐电休克在儿童精神分裂患者中的临床效果及对认知功能的影响研究 [J]. 国际精神病学杂志. 2018; 45; (4). 632 - 634.

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