Journal of International Psychiatry

【Abstract】 Objective To investigate the effect of brain function on the condition of depression. Methods 86 patients with depression from January 2015 to December 2016 were selected as the study subjects. The Hamilton Depression Scale (HAMD) was used to assess depression in patients. All patients underwent functional magnetic resonance imaging. Results 86 patients with HAMD score (23.5 ± 4.3) points. HAMD scores were positively correlated with ReHo values, including right inferior temporal gyrus (BA22), right cheek (BA18), left anterior cingulate cortex (BA36), left anterior wedge (BA9), left (BA25), the left posterior cingulate cortex (BA32) and the left frontal region (BA12). HAMD scores were negatively correlated with ReHo values, ​​including left central posterior (BA20), right central anterior (BA38), right lateral dorsolateral prefrontal cortex (BA11) and right superior temporal gyrus (BA41). Conclusion The ReHo values ​​of multiple brain regions in patients with depression are abnormal. The restenosis of brain function is mainly concentrated in the multiple brain regions such as default network and edge system. ReHo analysis can reflect the changes in brain function in patients with depression in resting state, and has become an effective tool for assessing the severity of depression.

【Key words】 Depression; Condition; Functional magnetic resonance imaging; ReHo; Resting state