| Abstract |
【 Abstract】objective: To discuss the effect of mirtazapine combined with escitalopram oxalate on major depressive disorder with sleep disorder of Sleep quality, quality of life and oxidative stress levels.Methods: 60 major depressive disorder with sleep disorder were selected from January 2015 to January 2017 in our Hospitals. According to Different medications, all patients were divided into observation group (30 cases)and control group(30 cases), observation group was given mirtazapine combined with escitalopram oxalate to treat, control group was given mirtazapine to treat, all were treated for 6 weeks. The quality of sleep, quality of life and the change of oxidative stress in two groups were compared and analyzed. Results: There was no significant difference in the quality, quality of life, and oxidative stress levels in the two groups(P>0.05). After treatment, two groups of patients with PSQI seven factors (sleep quality, sleep time, sleep time, sleep efficiency, sleep disturbance, hypnotic drugs and daytime activities) score and total score was reduced, the extent of observation group was higher than the control group, the total symptom score and daily life score of the observation group were higher than the control group, The levels of superoxide dismutase and nitric oxide of the observation group was higher than the control group, the total symptom score and daily life score of the o group were higher than the control group, hyperpropylene dialdehyde and plasma endothelial – 1 of the observation group was lower than the control group, the difference was statistically significant (P< 0.05).Conclusions: mirtazapine combined with escitalopram oxalate can effectively improve the sleep quality, quality of life and improved oxidative stress levels in major depressive disorder with sleep disorder, it’s worth for further clinical promotion.
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