| Abstract |
[Abstract] Objective: To study the effect of aripiprazole on the scores of psychiatric symptoms in elderly patients with Alzheimers disease complicated with mental disorders. Methods: 128 cases of elderly patients with Alzheimers disease complicated with mental disorders were selected from January 2016 to March 2017 in our hospital. They were randomly divided into control group and observation group, with 64 cases in each group. The control group received perphenazine treatment, and the observation group received aripiprazole treatment. The Behavioral Pathology in Alzheimers Disease Rating Scale (BEHAV-AD), the Personal and Social Performance Scale (PSP) and the Treatment Emergent Symptom Scale (TESS) score were compared between the two groups before and after treatment. Results: At 2, 4, 6, 8 weeks after treatment, the total scores of BEHAV-AD in the observation group were significantly lower than those in the control group (P<0.01), the scores of BEHAV-AD in the aspects of paranoia, delusion, hallucination, attack, abnormal activity, circadian rhythm disorder, emotional disorder, anxiety and fear in the observation group were lower than those in the control group (P<0.05). At 2, 4, 6, 8 weeks after treatment, the total score of PSP in the observation group was significantly higher than that in the control group(P<0.01). At 8 weeks after treatment, the score of TESS in the observation group was (6.88 + 1.36), which was significantly lower than that of the control group (8.78 + 2.13)(T=5.36,P=0.00).Conclusion: Aripiprazole can better treat patients with positive and negative mental abnormalities, improve the quality of life and social ability of patients, and the treatment of high safety, less adverse reaction of the vertebral body, it is worthy of clinical promotion
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