| Abstract |
【 Abstract】objective:To discuss the effect of Eszopiclone combined with Olanzapine on treatment of patients with schizophrenia of sleep.Methods:60 patients with schizophrenia were selected from January 2016 - December 2016 in author’ hospitals and were randomly divided into the experimental group and the control group with 30 cases in each group. The control group was given Eszopiclone(3mg/d,take it 30 minutes before bed), Olanzapine(2.5mg/d, take it 30 minutes before bed) was added to those in the experimental group, each group received the treatment respectively for 4 weeks as a course. The results of monitoring and mapping of polysomnography (PSG) were observed before treatment and after treatment for 4 weeks and compared with 60 healthy volunteers. Therapeutic effects and adverse reactions of two groups was compared. Results: Total sleep duration, REM sleep time, S2 time and SWS time of patients group was shorter than the normal group, wake time, S1 time was longer than the normal group, and the difference was statistically significant (P<0.05). After treatment, the total time of sleep, REM, S2 and SWS of two groups were all increased, and the experimental group increased more than the control group, two groups of arousal time and S2 time were shortened, and the experimental group was shorter than the control group, and the difference was statistically significant (P<0.05). Total effective rate of experimental group was higher than the control group, and the difference was statistically significant (P<0.05). There was no statistical significance in the two groups of fatigue, dizziness and oral pain(P>0.05), weight gain rate of experimental group was higher than the control group, and the difference was statistically significant (P<0.05). Conclusions: Eszopiclone combined with Olanzapine shows significant therapeutic efficacy for patients with schizophrenia, which can increase the total time of sleep, improve the quality of sleep, and high safety, it’s worth for further clinical promotion.
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