Journal of International Psychiatry

[Abstract] objective:To study the effect of paroxetine combined with psychological intervention in the treatment of peri-menopausal depression and brain-derived neurotrophic factor. Methods:From April 2016 to April 2017, 88 patients with peri-menopausal depression were divided into treatment group (n = 44) and control group (n = 44).The patients in both groups were treated with sequential hormone therapy, the control group took paroxetine orally on this basis, and the observation group was treated with psychological intervention of nursing and patient participation on the basis of the control group.Serum BDNF levels were measured before treatment, 2 weeks after treatment and 4 weeks after treatment.And according to the increase and decrease of HAMD score to compare the clinical efficacy of the two groups.Results:There was no significant difference in blood BDNF levels between the two groups 24 hours before intervention (P > 0.05). At 2 weeks after intervention, the levels of blood BDNF in both groups were significantly higher than those before intervention. The above indexes in the observation group were significantly higher than those in the control group (P < 0.05).The level of blood BDNF in the two groups was significantly higher than that in the control group at 4 weeks after intervention (P < 0.05), and the level of above indexes in the observation group was significantly higher than that in the control group (P < 0.05).The total effective rate in the observation group was significantly higher than that in the control group after intervention, and the difference between the two groups was significant (P =0.01, χ 2 = 5.44).There was no significant difference in HAMD scores between the two groups 24 hours before intervention (P > 0.05). The HAMD scores of the two groups were significantly lower than those before intervention at 2 weeks after intervention. The above indexes in the observation group were significantly lower than those in the control group (P < 0.05).The HAMD score of the two groups was significantly lower than that of the control group at the 4th week of intervention, and the level of the above indexes in the observation group was significantly lower than that in the control group (P < 0.05).There was no significant difference in Kupperman scores between the two groups 24 hours before intervention (P > 0.05). The Kupperman scores of the two groups at 2 weeks after intervention were significantly lower than those before intervention. And the level of above indexes in the observation group was significantly lower than that in the control group, and the difference was statistically significant (P < 0.05). The Kupperman score of the two groups was significantly lower than that of the control group at the 4th week of intervention, and the level of the above indexes in the observation group was significantly lower than that in the control group (P < 0.05).Conclusion:Paroxetine combined with psychological intervention in the treatment of postmenopausal depression has a good effect, can significantly improve the level of BDNF, reduce HAMD score and Kupperman score.

[keywords] paroxetine combined with psychological intervention; peri-menopausal depression; brain-derived neurotrophic factor