血清炎性细胞因子IL-1α、IL-6、IL-12、CRP变化与首发广泛性焦虑障碍发病相关性分析及作用机制分析
Analysis of the correlation between the changes of serum inflammatory cytokines IL-1 alpha, IL-6, IL-12, CRP and the onset of generalized anxiety disorder and its mechanism analysis
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| DOI |
| 刊名 |
Journal of International Psychiatry
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| 年，卷(期) |
2019, 46(1) |
| 作者 |
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| 作者单位 |
安阳市人民医院心理科，河南安阳，455000 ;
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| 摘要 |
【摘要】 探讨首发广泛性焦虑障碍患者外周血炎性细胞因子IL-1α、IL-6、IL-12、CRP变化与焦虑症状和执行功能的相关性，为疾病早期预测和早期干预提供临床依据。方法 选取我院确诊的首发广泛性焦虑障碍患者100例，在本院体检的健康对象50例作为对照组，选取时间2016年5月～2017年5月。酶联免疫分析检测血清中炎性细胞因子IL-1α、IL-6、IL-12、CRP的水平， 应用广泛性焦虑障碍量表(GAD-7)评估焦虑水平、状态-特质焦虑问卷（STAI）评定其总体焦虑程度和特质焦虑、状态焦虑水平，剑桥神经心理自动化成套测试软件(CANTAB)中内外空间成套转换测验(IED)测定执行功能。结果首发广泛性焦虑障碍组IL-1α、IL-6、IL-12、CRP等炎性细胞因子水平显著高于正常对照组（P<0.05）；状态焦虑SAI、特质焦虑TAI与IL-1α、IL-6、IL-12均呈显著正相关；外维转换错误数与外周血IL-1α、IL-6、IL-12、CRP水平呈正相关。结论 首发广泛性焦虑障碍患者存在炎性细胞因子和执行功能异常，和总体焦虑程度、状态焦虑及特质焦虑水平呈正相关。
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| Abstract |
【Abstract】Objective Patients with first-episode generalized anxiety disorder of peripheral blood inflammatory cytokines IL-1, IL-6, IL-12, CRP changes and correlation between anxiety symptoms and executive function,It provides a clinical basis for early prediction and early intervention of the disease.Methods100 cases of first diagnosed generalized anxiety disorder diagnosed in our hospital and 50 healthy subjects in our hospital were selected as control group. The time was from May 2016 to May 2017.Enzyme-linked immunosorbent assay was used to detect the levels of inflammatory cytokines IL-1 alpha, IL-6, IL-12, CRP in serum.The generalized anxiety disorder scale (GAD-7) was used to evaluate the anxiety level and the State Trait Anxiety Inventory (STAI) was used to assess the overall anxiety level, trait anxiety and state anxiety level.The implementation function of the complete set of internal and external space conversion test (IED) was measured in the Cambridge neuropsychological automation complete test software (CANTAB).Results The levels of IL-1 alpha, IL-6, IL-12, CRP and other inflammatory cytokines in the first generalized anxiety disorder group were significantly higher than those in the normal control group (P<0.05);State anxiety SAI and trait anxiety TAI were positively correlated with IL-1 alpha, IL-6 and IL-12;There was a positive correlation between the number of external dimension conversion errors and the levels of IL-1 alpha, IL-6, IL-12 and CRP in peripheral blood.Conclusion There was a positive correlation between inflammatory cytokines and executive function abnormalities in the first episode of generalized anxiety disorder and the level of overall anxiety, state anxiety and trait anxiety.
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| 关键词 |
【关键词】血清炎性细胞因子、焦虑障碍、IL-1α、IL-6、IL-12、CRP
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| KeyWord |
【Key words】Serum inflammatory cytokines、Anxiety disorder、IL-1α、IL-6、IL-12、CRP
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| 基金项目 |
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| 页码 |
60-62 |
邓越峰*.
血清炎性细胞因子IL-1α、IL-6、IL-12、CRP变化与首发广泛性焦虑障碍发病相关性分析及作用机制分析 [J].
国际精神病学杂志.
2019; 46; (1).
60 - 62.