Journal of International Psychiatry

Abstract:Objective: To investigate the efficacy and safety of sodium valproate combined with risperidone in the treatment of epileptic mental disorders.Methods: 168 patients with epileptic mental disorder in our hospital from January 2014 -December 2016 were selected as the research subjects. They were randomly divided into the control group and the observation group.The control group was treated with sodium valproate, and the observation group was treated with risperidone on the basis of the treatment.The PANSS score, cognitive function and adverse reaction were compared in the two groups, and the clinical efficacy was evaluated.Results: After treatment, the positive scale, negative scale, mental pathology and total score of the two groups were significantly decreased, and the observation group was significantly lower than that of the control group, with significant difference (P<0.05).The total effective rate of treatment in the observation group was 90.48% significantly higher than that (77.38%）of the control group(P<0.05).Before and after treatment, there was no difference in MMSE scores between the two groups (P>0.05).After treatment, the score of TESS in the observation group was (8.34+2.71), and the score of TESS in the control group was (8.12+2.64) (P>0.05).Conclusion: The effect of sodium valproate combined with risperidone in the treatment of epileptic mental disorders is significant. It has little effect on cognitive function and light side effect. It is worth popularizing.

Key words: sodium valproate; Risperidone; epileptic psychotic disorder