Journal of International Psychiatry

Abstract: Objective: To explore the clinical efficacy of high frequency repetitive transcranial magnetic stimulation combined with paliperidone in the treatment of senile schizophrenic negative symptoms and to analyze the safety of the patients. Methods: A total of 60 elderly women with schizophrenia negative symptoms were selected in our hospital from January 2016 to November 2017. According to the random number table method, the patients were divided into control group and observation group, 30 cases in each group. Paliperidone was used in the two groups, and the observation group combined with high frequency repetitive transcranial magnetic stimulation on this basis, and the control group was given pseudo stimulation for 8 weeks. PANSS scale was used to evaluate the improvement and curative effect of patients. The STROOP color word interference test was used to evaluate the cognitive function of patients, and the adverse reaction symptom scale (TESS) was used to evaluate the adverse reactions. Results: After 8 weeks of treatment, the negative symptoms, positive symptoms, general psychopathological points and total scores of the two groups were reduced, and the observation group was all lower than the control group(P<0.05). The two groups of nomenclature scores increased, and the score of the observation group was higher than that of the control group (P<0.05). The total effective rate of the observation group was higher than the control group(P<0.05). There was no difference in the incidence of adverse reactions between the two groups（P>0.05）. Conclusion: For the elderly schizophrenic patients with negative symptoms, giving paliperidone treatment combined with high-frequency repetitive transcranial magnetic stimulation, could obviously promote the negative symptoms of patients, improve the curative effect, and to promote the recovery of cognitive function, high safety, worthy of clinical application.

Keyword: paliperidone; high frequency repetitive transcranial magnetic stimulation; senile; schizophrenia; negative symptoms