| Abstract |
Objective: To study the changes of serum copper (Cu), iron (Fe), zinc (Zn), chromium (Cr) and selenium (Se) and other trace elements in schizophrenic population, and to explore the correlation between these trace elements and the weight and duration of schizophrenia. Methods: from February 2017 to February 2018, 90 schizophrenic patients in our hospital were selected as case group, and 90 normal healthy persons in our hospital during the same period were selected as control group. The contents of serum Cu, Fe and Zn in two groups were detected and compared by flame atomic absorption spectrometry. The contents of Cr and Se in serum of two groups were detected and compared by graphite furnace atomic absorption spectrometry. The correlation of weight, course of disease and Cu, Fe, Zn and Cr levels in patients with schizophrenia was analyzed by Pearson correlation. Results: the patients serum Cu, Fe levels were (924.37 ±17.85)ng/mL, (1314.25 ± 156.33) ng/mL, were significantly higher than the control group (P<0.01); group Cr, serum Zn, Se levels were (782.63 ± 24.51) ng/mL ,(53.14 ± 3.03)ng/mL, (95.46 ± 5.38) ng/ mL, were significantly lower than the control group (P<0.01). The serum levels of Cu, Fe, Zn, Cr and Se in the patients with different age groups were basically consistent, and there was no significant difference (P>0.05). After Pearson correlation analysis, the serum levels of Cu, Fe, Zn, Cr, Se and other trace elements were not related to the body weight and the course of disease. Conclusion: serum Cu, Fe, Zn, Cr, Se and other trace elements have abnormal changes in the population of schizophrenia, but there is no association with the age、body weight and the course of the disease.
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