Journal of International Psychiatry

[Abstract] Objective To investigate the clinical effect of rosuvastatin in the treatment of mild depression and anxiety after acute cerebral infarction.Methods 100 patients with mild acute cerebral infarction received in our hospital from January 2015 to January 2018 were selected. Patients were divided into observation group and control group according to random number table method. The control group was treated with conventional antiplatelet aggregation, improved circulation and nutritional nerve treatment. The observation group was treated with rosuvastatin on the basis of the control group. The emotional state of the patients before and after treatment was evaluated by the self rating Anxiety Scale (SAS) and the self rating Depression Scale (SDS). The clinical therapeutic effects of the two groups were compared and analyzed. The changes of blood lipid and serum hypersensitivity C reactive protein (Hs-CRP) before and after treatment, the recovery of nerve function in the two groups and the patients in the two groups were compared and analyzed. The prognosis of the patients.Results Before treatment, there was no significant difference in SAS and SDS scores between the two groups (P > 0.05). After the treatment, the scores of SAS and SDS were lower than those before the treatment, and the SAS and SDS scores in the observation group were significantly lower than those in the control group, the difference was statistically significant (P < 0.05). There was no significant difference in the stroke score (NIHSS) of the National Institutes of Health (NIHSS) before treatment (P>0.05), and the NIHSS scores were significantly lower after treatment, and the observation group was significantly lower than the control group. The difference between the two groups was statistically significant (P<0.05). The clinical efficacy (86%) of the observation group after treatment was significantly better than that of the control group (68%), and the difference between the two groups was statistically significant (χ2=4.574, P=0.033). The plasma triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) and Hs-CRP were significantly improved after treatment in the two groups, and the levels of the observation group were significantly lower than those in the control group. The differences in the two groups were statistically significant (P<0.05). The two groups were treated with high density fat. Protein cholesterol (HDL-C) did not change significantly before treatment (P>0.05). The good rate of the observation group after treatment (98%) was significantly higher than that of the control group (86%), the difference was statistically significant (χ2=4.891, P=0.027).Conclusion Rosuvastatin has good therapeutic effect on patients with mild depression and anxiety after acute cerebral infarction. It can effectively improve the patients bad mood, help to recover the nerve function and reduce the level of blood lipid and Hs-CRP in patients. It is worthy of clinical promotion and application.

【Keywords】rosuvastatin; acute cerebral infarction; depression and anxiety; neurological function; mental state