Journal of International Psychiatry

【Abstract】Objective: To analyze the effect of antidepressant therapy on the depression status of patients with advanced non-small cell lung cancer (NSCLC) and the changes of T cell subsets and NK cells. Methods: 87 patients with advanced NSCLC who were treated in our hospital from August 2015 to September 2018 were divided into observation group and control group by random number table method. The control group received conventional chemotherapy only, while the observation group was given antidepressant treatment on the basis of the control group. The improvement of depressive state was compared between the two groups under different treatment modes, and the changes of T cell subsets and NK cells in the two groups were analyzed. Result: The relief effect of depression in the observation group was significantly higher than that in the control group (P<0.05). The relief rate of depression in the observation group was significantly higher than that of the control group (P< 0.05); in the observation group, the levels of CD3+, CD4+, and CD8+ in the T cell subsets were significantly higher than those in the control group, and CD4+/CD8+ was significantly lower than that in the control group (P<0.05). The group was more significant (P < 0.05). Conclusion: In the course of routine chemotherapy for patients with NSCLC, anti-depression adjuvant therapy with fluoxetine can significantly improve the bodys immune ability, and it can also improve the bodys immunity.

[Key words] antidepressant therapy; advanced; non-small cell lung cancer; T cell subsets; NK cells