Journal of International Psychiatry

[Abstract] Objective To analyze the changes of negative emotion and serum cytokine levels in patients with anxiety and depression after stroke using paroxetine. Methods A total of 111 patients with post-stroke anxiety and depression were enrolled in our hospital by random number table. 55 patients in the control group were treated with sertraline hydrochloride, and 56 patients in the observation group were treated with paroxetine. After treatment, clinical efficacy, neurological function, anxiety and depression Changes in mood, serum cytokine levels, and safety. Results The total effective rate and 5-HT level in the observation group were higher than those in the control group. The NIHSS, HAMD, HAMA scores and Hcy and IL-1 levels were lower than those in the control group (P<0.05). The incidence of adverse reactions was 8.93% lower than that of the control group. Group 12.73% (P>0.05). Conclusion Paroxetine can effectively improve the imbalance of inflammatory factors in patients with post-stroke depression, change neurobiological properties, promote neurotransmitter transmission and recovery of neurological function, eliminate negative emotions of anxiety and depression, and have high safety and effectiveness.

[Key words] paroxetine; stroke; depression; anxiety; serum cytokines