| Abstract |
[Abstract] Objective To study the expression situation of serum BDNF, SP and IL-18 in elderly patients with depression and its clinical significance. Methods A total of 128 elderly patients with depression treated in our hospital from the hospital from July 2016 to January 2018 were selected as the study subjects. According to the Self-rating depression scale (SDS) score, they were divided into mild depression group (40 cases), moderate depression group (45 cases), and severe depression group (43 cases). Another 40 healthy people were selected as the control group. The serum levels of BDNF, SP, IL-18 and the Hamilton Depression Scale (HAMD), the Hamilton Anxiety Scale (HAMA), and the Quality of Life Scale (WHOQOL-BREF) were compared among the four groups. Results Serum DBNF levels in the control group were significantly higher than those in the moderate and severe depression groups. SP and IL-18 levels were significantly lower than those in the mild, moderate, and severe depression groups (P<0.05). There was no significant difference in serum DBNF levels between the control group and the mild depression group (P>0.05). The HAMD and HAMA scores of the control group were significantly lower than those of the mild, moderate, and severe depression groups, and the differences were statistically significant (P<0.05). The total score of WHOQOL-BREF in the control group was significantly higher than that in the mild, moderate, and severe depression groups, and the difference was statistically significant (P<0.05). Conclusion Serum BDNF, SP, IL-18 levels have a high clinical value in predicting the degree of depression in elderly patients, and can provide a scientific basis for the quality of life and treatment effect of patients with prognosis.
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