| Abstract |
Abstract: Objective: To study the effects of different doses of dexmedetomidine combined with sufentanil on postoperative cognitive function in gynecological laparoscopic patients. Methods: 120 patients who underwent gynecologic laparoscopic surgery in our hospital from January 2016 to January 2018 were randomly divided into control group, A、B、C group, each group was 30 cases. In group A, B and C, dexmedetomidine was added to the anesthesia induction period and maintenance period, the dose were 0.3, 0.4, 0.5 ug/(kg·h). The control group was given equal volume of normal saline at the same time. Observe and record the occurrence of adverse reactions, extubation time, recovery time, recovery time, postoperative 24h pain, cognitive function score and POCD occurrence. Results: The recovery time, extubation time and directional recovery time in group A, B and C were significantly lower than those in control group. recovery time, extubation time and directional recovery time in group C were significantly lower than those in group A（P＜0.05）; The incidence of adverse reactions in group A, B and C was higher than the control group, the incidence of adverse reaction in group C was higher than group A and B（P＜0.05）. The VAS scores of 4h, 8h and 24h in group A, B and C were all lower than the control group at the same time, the scores of 4h, 8h and 24h in B and C group were lower than group A（P＜0.05）; The MoCA scores of the 1、3、7d after operation, the, A, B and C groups were all higher than control group（P＜0.05）. The incidence of POCD in group A, B and C was lower than the control group（P＜0.05）. Conclusion: For patients undergoing gynecologic laparoscopic surgery, the addition of dexmedetomidine during anesthesia could relieve postoperative pain, and promote postoperative cognitive function recovery, and reduce the incidence of POCD，the recommended dose is 0.4 ug/(kg·h).
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