Journal of International Psychiatry

【Abstract】 Objective: To explore the relationship between the changes of serum acute- phase reaction protein (C-reactive protein, Albumin, Prealbumin) and the changes of senile depression. Methods: 94 patients old depression were randomly selected. To determined the concentrations of serum C-reactive protein, albumin and prealbumin. Hamilton Depression Rating Scale(HAMD) and Hamilton anxiety scale(HAMA) were used to estimate depression and anxiety symptoms. The detection and assessment were completed before treatment and the end of treatment for 4 weeks. The changes of serum acute phase reaction protein concentrations in patients before and after treatment were compared. Results: After treatment in 94 patients old depression, the concentration of C-reactive protein was significantly higher than the concentration after treatment, while the concentration of Albumin and Prealbumin was significantly lower than the concentration after treatment, and they all have statistical significance (tCRP=7.523,tAlb=-5.808,tPA=-7.373,P=0.000). After treatment, the scores of HAMD and HAMA scales in 94 cases of senile depression were significantly decreased, with statistical significance (tHAMD=33.506, tHAMA=39.023,P=0.000). Conclusions: Patients with senile depression have acute phase reaction protein changes; CRP, Alb and PA are significantly correlated with the severity of senile depression, which can be used as biochemical indicators for clinical evaluation of senile depression.

Senile depression; C-reactive protein; Albumin; Prealbumin