Journal of International Psychiatry

【Abstract】Objective To investigate the efficacy of different lateral dorsolateral prefrontal repetitive transcranial magnetic stimulation (rTMS) in the treatment of depression and its effect on time perception.Methods 110 patients with depression admitted to our hospital from December 2016 to June 2018 were selected and divided into group A and group B with 55 cases each according to random number table method.Both groups were treated with rTMS in the dorsolateral prefrontal lobe. Group A was stimulated from the right side and Group B was stimulated from the left side. Both groups were treated for 8 weeks.Hamilton Depression Scale (HAMD) was used to assess the degree of depression before treatment, 4 weeks after treatment, 6 weeks after treatment and 8 weeks after treatment.Serum levels of neuron enolase (NSE) and brain-derived neurotrophic factor (BDNF) were measured before treatment and after treatment.The duplication errors of 600ms and 3S time intervals before and after treatment were analyzed and the safety of treatment was evaluated.Results The HAMD scores of the two groups at 4, 6 and 8 weeks after treatment were lower than those before treatment (P < 0.05), but there was no significant difference between the two groups (P > 0.05).After treatment, serum NSE in group A was lower than that in group B, and serum BDNF was higher than that in group B (P < 0.05).The duplication error of 600 ms and 3 s after treatment in group A was lower than that in group B (P < 0.05).There was no significant difference in the incidence of headache, tinnitus, dry mouth, scalp discomfort and fatigue between groups A and B (P > 0.05).Conclusion The treatment of left and right dorsolateral prefrontal lobe rTMS can improve the condition of depression patients, but compared with left side, right side stimulation can further improve the level of serum NSE, BDNF and time perception of patients, and has higher clinical value.