Journal of International Psychiatry

Objective To analyze the changes of postoperative cognitive function and the incidence of spasticity in elderly patients with fractures after different sedation depth anesthesia. Methods 105 elderly patients with fractures in our hospital were divided into two groups according to the random number table method. 52 cases of anesthesia index (CSI) 50 in the control group and 53 cases of anesthesia index (CSI) in the observation group were compared. The cerebrospinal fluids of the two groups were compared at different time points after anesthesia. Marker levels, serum neuron levels, cognitive function before and after surgery, and incidence of postoperative delirium. Results The levels of T2, T3, T4 Aβ 1-42, T-Tau and P-Tau in the observation group were lower than those in the control group. The levels of T1, T2, T3, S100β and NSE were lower than those in the control group. The MMSE scores at 3 and 7 days after operation were higher than those in the control group. The incidence of sputum was lower than that of the control group (P<0.05). Conclusion Maintaining CSI at 80 hours can effectively reduce the cognitive function of patients with postoperative fractures and reduce the incidence of postoperative delirium.

sedation depth; old age; fracture; postoperative cognitive function;delirium