Journal of International Psychiatry

Objective To analyze the effects of sertraline treatment and the changes of negative mood and cardiac function indexes in patients with acute myocardial infarction complicated with emotional disorder. Methods Eighty-nine patients with acute myocardial infarction and emotional disorder who were treated in our hospital from June 2018 to June 2019 were selected and divided into 44 patients in the control group and 45 patients in the observation group according to the order of admission. Conventional treatment of myocardial infarction. Patients in the control group increased psychological therapy. Patients in the observation group added sertraline orally to the control group. After treatment, the cardiac output (CO), left ventricular ejection fraction (LVEF), and heart were compared. Stroke Volume (SV), Hamilton Depression Rating Scale (HAMD), Hamilton Anxiety Scale Rating (HAMA), Serum Endothelin-1 (ET-1), Hypersensitivity-C Reactive Protein (hs-CRP), Human Fibrinolysis Changes of zymogen activator inhibitor factor-1 (PA-1) and angiotensin Ⅱ (Ang Ⅱ) levels. Results After treatment, the levels of hs-CRP, Ang Ⅱ, ET-1, PA-1 and HAMD and HAMA scores in the observation group were lower than those in the control group, and the levels of SV, CO and LVEF were higher than those in the control group (P <0.05). Conclusion Sertraline combined with psychotherapy can effectively eliminate the negative emotions of patients with acute myocardial infarction combined with emotional disorders, improve neurohumoral function and promote cardiac function recovery.

Sertraline; Psychotherapy; Acute myocardial infarction; Affective disorder; Anxiety and depression; Heart function