丁苯酞注射液对缺血性脑卒中认知障碍者认知功能及相关电位的影响
Effects of Butylphthalide injection on Cognitive Function and Related Potentials in Cognitive Impairment Patients with Ischemic Stroke
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| DOI |
| 刊名 |
Journal of International Psychiatry
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| 年，卷(期) |
2020, 47(3) |
| 作者 |
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| 作者单位 |
山东能源新汶矿业集团中心医院神经内一科 ;
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| 摘要 |
研究丁苯酞注射液对缺血性脑卒中认知障碍者认知功能及相关电位的影响。方法 选择2017年6月到2019年3月本院120例缺血性脑卒中认知障碍者作为研究对象，随机分为常规治疗的60例对照组，丁苯酞注射液与常规治疗的60例试验组。比较两组的蒙特利尔认知评估量表(Montreal cognitive assessment，MoCA)、神经功能缺损评分量表(Neurological deficit score，NDS)、事件相关电位(Event related potential，ERP)、并发症。结果 对照组治疗后的MoCA评分显著低于试验组，NDS评分显著高于试验组，差异均有统计学意义(P<0.001)。两组治疗后的P1、N1、P2潜伏期比较，差异均无统计学意义(P>0.05)；对照组治疗后的N2、P3潜伏期显著高于试验组，差异均有统计学意义(P<0.001)。对照组治疗后的P1、N1、P2、N2、P3波幅显著低于试验组，差异均有统计学意义(P<0.05)。对照组并发症发生率8.33%与试验组并发症发生率5.00%比较，差异无统计学意义(P>0.05)。结论 丁苯酞注射液可显著改善缺血性脑卒中认知障碍者的认知功能，降低其神经功能缺损程度。
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| Abstract |
Objective To study the effects of Butylphthalide injection on cognitive function and related potentials in cognitive impairment patients with ischemic stroke. Methods A total of 120 patients with cognitive impairment of ischemic stroke were selected from our hospital from June 2017 to March 2019 were selected as the study subjects. They randomly divided into 60 cases of conventional treatment control group, 60 cases of Butylphthalide injection and conventional treatment study group. The Montreal cognitive assessment (MoCA), neurological deficit score (NDS), event related potential (ERP), and complications between the two groups were compared. Results After treatment, the MoCA score of the control group was significantly lower than that of the test group, and the NDS score was significantly higher than that of the study group. The differences were statistically significant (P<0.001). There was no significant difference in P1, N1, and P2 latency between the two groups after treatment (P>0.05). The latency of N2 and P3 in the control group was significantly higher than that in the study group after treatment, and the differences were statistically significant (P<0.001). The P1, N1, P2, N2, and P3 amplitudes of the control group after treatment were significantly lower than those of the study group, and the differences were statistically significant (P<0.05). The complication rate in the control group was 8.33% and the complication rate in the test group was 5.00%. There was no significant difference (P>0.05). Conclusion Butylphthalide injection can significantly improve the cognitive function and reduce the degree of neurological deficits in patients with ischemic stroke and cognitive impairment.
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| 关键词 |
丁苯酞；缺血性脑卒中；认知障碍；相关电位；认知功能
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| KeyWord |
Butylphthalide injection; Ischemic Stroke; Cognitive Impairment; Related Potentials; Cognitive Function
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| 基金项目 |
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| 页码 |
536-539 |
史正瑞*.
丁苯酞注射液对缺血性脑卒中认知障碍者认知功能及相关电位的影响 [J].
国际精神病学杂志.
2020; 47; (3).
536 - 539.