Journal of International Psychiatry

Objective To investigate the effects of escitalopram on vascular endothelial function, PAI-1, anxiety and depression in patients with acute myocardial infarction after intervention. Methods A total of 81 patients with anxiety and depression after interventional intervention in our hospital between April 2018 and April 2019 were treated as the observation object. Traditional treatment) and observation group (41 patients received conventional treatment after intervention + escitalopram treatment), and vascular endothelial function and plasminogen activator inhibitor-1 (PAI- 1) The Hamilton Anxiety Scale (HAMA) and Hamilton Depression Scale (HAMD) were used to evaluate patients anxiety and depression. Results After treatment, NO in the observation group was significantly higher than that in the control group, and ET-1 and PAI-1 were significantly lower than those in the control group. The differences between the groups were significant (P <0.05). In the control group, the difference was significant (P <0.05). Conclusion Escitalopram can significantly alleviate the adverse mood of patients with anxiety and depression after interventional intervention in acute myocardial infarction, improve vascular endothelial function, reduce coronary vascular endothelial damage, and inhibit psychological and physiological stress responses in patients. It is worthy of clinical recommendation.

escitalopram; acute myocardial infarction; vascular endothelial function; anxiety; depression