齐拉西酮合并碳酸锂治疗双相情感障碍躁狂发作的临床疗效及安全性评价
Clinical efficacy and safety of ziprasidone combined with lithium carbonate in the treatment of manic episode of bipolar disorder
ES评分 0
| DOI |
| 刊名 |
Journal of International Psychiatry
|
| 年，卷(期) |
2021, 48(1) |
| 作者 |
|
| 作者单位 |
许昌市建安医院 ;
|
| 摘要 |
目的：评价齐拉西酮合并碳酸锂治疗双相情感障碍躁狂发作的临床疗效及安全性。方法：随机选取2018年2月——2019年3月期间我院收治的70例双相情感障碍躁狂发作患者，将其分成对照组、研究组，一组35例。对照组单用碳酸锂治疗；研究组联合碳酸锂与齐拉西酮治疗。对比观察两组患者的临床疗效。结果：研究组总有效率97.1%（34/35）高于对照组85.7%（30/35），二组数据比较，差异有统计学意义（P<0.05）；研究组治疗后血清神经递质指标优于对照组，二组比较，有统计学意义（P<0.05）；研究组2例不良反应，对照组共7例，比较显示，研究组发生率低于对照组，差异有统计学意义（P<0.05）；6个月后，研究组0例复发，对照组3例复发，比较复发率，研究组低于对照组，有统计学差异（P<0.05）。结论：齐拉西酮合并碳酸锂治疗双相情感障碍躁狂发作，疗效显著，可改善血清神经递质，且不良反应少，复发率低。
|
| Abstract |
Objective: To evaluate the efficacy and safety of ziprasidone combined with lithium carbonate in the treatment of bipolar disorder manic episode. Methods: 70 patients with bipolar disorder manic episode admitted to our hospital from February 2018 to March 2019 were randomly selected and divided into control group and study group, with 35 cases in one group. The control group was treated with lithium carbonate alone; the study group was treated with lithium carbonate and ziprasidone. The clinical effects of the two groups were compared. Results: the total effective rate of the study group was 97.1% (34 / 35) higher than that of the control group, 85.7% (30 / 35), the difference was statistically significant (P < 0.05); the serum neurotransmitter index of the study group was better than that of the control group after treatment, the difference was statistically significant (P < 0.05); the adverse reactions of the study group were 2 cases, 7 cases in the control group, the comparison showed that the incidence of the study group was lower than that of the control group, poor The difference was statistically significant (P < 0.05); six months later, there was no recurrence in the study group and 3 in the control group. The recurrence rate in the study group was lower than that in the control group (P < 0.05). Conclusion: ziprasidone combined with lithium carbonate in the treatment of bipolar disorder manic episode, the effect is significant, can improve the serum neurotransmitter, and less adverse reactions, low recurrence rate.
|
| 关键词 |
齐拉西酮；碳酸锂；双相情感障碍；躁狂发作；临床疗效；安全性
|
| KeyWord |
ziprasidone; lithium carbonate; bipolar disorder; manic episode; clinical efficacy; safety
|
| 基金项目 |
|
| 页码 |
42-44 |
邵国艳*.
齐拉西酮合并碳酸锂治疗双相情感障碍躁狂发作的临床疗效及安全性评价 [J].
国际精神病学杂志.
2021; 48; (1).
42 - 44.