奥拉西坦治疗老年脑出血后认知功能障碍的疗效和安全性
Efficacy and safety of oxiracetam in the treatment of cognitive dysfunction after cerebral hemorrhage in the elderly
ES评分 0
| DOI |
| 刊名 |
Journal of International Psychiatry
|
| 年，卷(期) |
2021, 48(1) |
| 作者 |
|
| 作者单位 |
中国人民解放军联勤保障部队第九八九医院 ;
|
| 摘要 |
[目的]观察评价奥拉西坦治疗老年脑出血后认知功能障碍的疗效和安全性。[方法]以2018年4月至2019年5月为时间段，选择我院收治的102例老年脑出血患者作为对象。根据随机数表法进行分组，设为对照组、研究组，一组51例。两组病人均实施常规额颞瓣开颅手术，基于此，对照组接受常规治疗，研究组配合口服奥拉西坦胶囊。对比观察两组患者的临床疗效。[结果]第一，评价认知功能，研究组治疗后MoCA评分、MMSE评分均高于对照组，二组比较显示P<0.05，提示有统计学意义。第二，研究组共2例出现不良反应，对照组共7例出现不良反应，研究组发生率低于对照组，二组比较，结果显示P<0.05，提示两组数据有统计学意义。[结论]老年脑出血术后给予奥拉西坦治疗，可改善认知功能障碍，不良反应少，安全性高。
|
| Abstract |
[Objective] to observe and evaluate the efficacy and safety of oxiracetam in the treatment of cognitive dysfunction after cerebral hemorrhage in the elderly. [Methods] from April 2018 to may 2019, 102 elderly patients with cerebral hemorrhage in our hospital were selected as subjects. According to the method of random number table, 51 cases were divided into control group and study group. The patients in the two groups were operated with conventional frontotemporal flap craniotomy. Based on this, the control group received conventional treatment, and the study group took oral oracetam capsule. The clinical effects of the two groups were compared. [results] first, to evaluate the cognitive function, the MOCA score and MMSE score of the study group were higher than those of the control group after treatment, and the comparison between the two groups showed that P < 0.05, suggesting that there was statistical significance. Second, there were 2 adverse reactions in the study group and 7 in the control group. The incidence of the study group was lower than that of the control group. The results showed that P < 0.05, indicating that the data of the two groups were statistically significant. [Conclusion] oxiracetam can improve the cognitive function of elderly patients with intracerebral hemorrhage.
|
| 关键词 |
奥拉西坦；老年；脑出血；认知功能障碍；疗效；安全性
|
| KeyWord |
oxiracetam; old age; cerebral hemorrhage; cognitive dysfunction; efficacy; safety
|
| 基金项目 |
|
| 页码 |
102-104 |
王兴克*.
奥拉西坦治疗老年脑出血后认知功能障碍的疗效和安全性 [J].
国际精神病学杂志.
2021; 48; (1).
102 - 104.