STM2457经YTHDF1/EIF3C抑制Huh-7肝癌细胞增殖-华夏医学-CSCIED科技核心评价数据库-手机版

STM2457经YTHDF1/EIF3C抑制Huh-7肝癌细胞增殖

STM2457 inhibits the proliferation of Huh?7 liver cancer cell sthrough YTHDF1/EIF3C

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DOI	10.19296/j.cnki.1008-2409.2025-01-004
刊名	华夏医学 ACTA MEDICINAE SINICA
年，卷(期)	2025, 38(01)
作者	庄家敏1赵培培1,2杨媛媛1,2周雨佳1刘栩3SREANG Lyly4涂剑1,
作者单位	1中国广西桂林；2中国广西桂林；3中国广西桂林；4中国广西桂林
摘要	论文探究甲基转移酶3（METTL3）抑制剂STM2457对Huh-7人肝癌细胞增殖能力的作用及其机制。结果表明，相较于癌旁组织，肝癌组织中增殖标志物PCNA表达显著增强的同时，METTL3、YTHDF1、EIF3C的表达也显著增强；STM2457可显著抑制Huh-7细胞的增殖能力（P<0.01）,靶向抑制METTL3表达的同时，还可下调YTHDF1、EIF3C、PCNA的表达；METTL3 siRNA下调METTL3表达的同时，还可同步下调YTHDF1、EIF3C、PCNA的表达。
Abstract	The study investigated the effects of the methyltransferase 3 (METTL3) inhibitor STM2457 on the proliferation ability of Huh?7 human hepatocellular carcinoma cells and its underlying mechanisms. The results showed that compared to adjacent non?tumor tissues, the expression of the proliferation marker PCNA was significantly enhanced in hepatocellular carcinoma tissues, accompanied by significantly increased expression of METTL3, YTHDF1, and EIF3C. STM2457 significantly inhibited the proliferation ability of Huh?7 cells (P?
关键词	STM2457;甲基转移酶3;YTH N6-甲基腺苷RNA结合蛋白1;真核起始因子3;肝癌增殖;
KeyWord	STM2457;methyltransferase 3;YTH N -methyladenosine RNA-binding protein 1 ;eukaryotic initiation factor 3;proliferation of liver cancer
基金项目
页码	22-27

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引用本文

庄家敏赵培培,杨媛媛,周雨佳刘栩SREANG Lyly涂剑. STM2457经YTHDF1/EIF3C抑制Huh-7肝癌细胞增殖 [J]. 华夏医学. 2025; 38; (01). 22 - 27.

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