| Abstract |
Objective To explore the clinical efficacy of eszopiclone combined with mirtazapine on patients with chronic insomnia. Methods 82 cases of chronic insomnia patients were randomly divided into a study group of 42 cases a control group of 40 cases by random number method. The control group was given oral eszopiclone (1.5 ~ 3mg / d). The research group was combined with oral mirtazapine on the basis of the control group (15 ~ 30mg / d) treatment. Before treatment, 1, 2, and 4 weeks after treatment, the two groups of subjects were evaluated by the Pittsburgh Sleep Index (PSQI) and Adverse Reaction Scale (TESS). The reduction rate is evaluated for efficiency. At the same time, overnight sleep breathing monitoring (PSG) was performed on the two groups of subjects before treatment and 4 weeks after treatment, and the changes of the two groups before and after treatment were observed and compared by the PSG sleep index. Results After treatment, the total PSQI scores of the two groups were gradually lower than before treatment. After 4 weeks of treatment, the effective rate of the study group was 92.9%, and the control group was 80%. The difference was statistically significant (χ2=11.296，P=0.010).It was significantly lower than the control group, and the difference was statistically significant (P<0.05). After treatment, both groups showed prolonged TST, significantly reduced ATA and AT, significantly reduced SL, significantly increased SE, significantly reduced REM latency, and prolonged REM and N2 time, which were statistically significant differences from those before treatment ((P<0.05); Among them, the study group had a significant increase in N3 time and ratio before treatment, and the difference was statistically significant ((P<0.05). After treatment, the study group increased the TST, N2, N3 time, and the ratio of N3, and decreased the SL, ATA, and AT, and the increase of SE was significantly higher than that of the control group, and the difference was statistically significant (P<0.05).Conclusion Eszopiclone combined with mirtazapine in the treatment of chronic insomnia is more effective than single use of eszopiclone; high safety, can deepen sleep, reduce awakening, and is worth clinical promotion.
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