Journal of International Psychiatry

Objective To study the clinical effects of fluoxetine and amitriptyline on emotional disorders after alcohol dependence withdrawal. Methods Ninety-four patients with affective disorder after alcohol dependence withdrawal in our hospital from December 2018 to December 2019 were selected as the research objects, and randomly divided into the control group (52 cases) treated with amitriptyline and 52 patients were set as the study group treated with fluoxetine group. The two groups were compared for the manic scale (BRMS), the self-rating anxiety scale (SAS), the self-rating depression scale (SDS), neuropeptide Y (NPY), serotonin (5-HT), and adverse reactions. Results The BRMS, SAS, and SDS scores in the control group after treatment were significantly higher than those in the study group, and the differences were statistically significant (P<0.05). The NPY and 5-HT in the control group after treatment were significantly lower than those in the study group, and the differences were statistically significant (P<0.05). The incidence of adverse reactions in the control group was 13.46% and the incidence of adverse reactions in the study group was 7.69%. There was no significant difference (P>0.05). Conclusion In the treatment of emotional disorders after alcohol-dependent withdrawal, fluoxetine improves mania, anxiety, and depression more than amitriptyline, which can significantly increase the levels of NPY and 5-HT and promote clinical efficacy.

Fluoxetine; Amitriptyline; Ethanol Dependence; Affective Disorder