Adhesion G-Protein Coupled Receptors in Neurological and Psychiatric Disorders-Journal of Psychiatry and Brain Science-CSCIED科技核心评价数据库-手机版

Adhesion G-Protein Coupled Receptors in Neurological and Psychiatric Disorders

Adhesion G-Protein Coupled Receptors in Neurological and Psychiatric Disorders

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DOI	10.20900/jpbs.20250017
刊名	Journal of Psychiatry and Brain Science JPBS
年，卷(期)	2025, 10(6)
作者	Brandon H. Lee,Christina M. Meyer,David J. Speca,Elva Díaz*,
作者单位	Department of Pharmacology, School of Medicine, University of California, Davis, CA 95616, USA ;
摘要	The adhesion G-protein coupled receptors (aGPCRs) are a family of 33 G-protein receptors consisting of ADGRA1-3, ADGRB1-3, ADGRC1-3, ADGRD1-2, ADGRE1-5, ADGRF1-5, ADGRG1-7, ADGRL1-4, and ADGRV1. Recent studies have unveiled the role of aGPCRs in numerous brain functions, including in neurodevelopment, synapse formation and maintenance, establishment of the blood-brain barrier, and myelination. Further, dysfunction of aGPCRs have been associated with disorders such as gliomas, depression, and epilepsy, among many others. Herein, we review generalized properties of aGPCRs, their brain-specific expression, associations with neurological and psychiatric diseases, and potential as future pharmacological targets.
Abstract	The adhesion G-protein coupled receptors (aGPCRs) are a family of 33 G-protein receptors consisting of ADGRA1-3, ADGRB1-3, ADGRC1-3, ADGRD1-2, ADGRE1-5, ADGRF1-5, ADGRG1-7, ADGRL1-4, and ADGRV1. Recent studies have unveiled the role of aGPCRs in numerous brain functions, including in neurodevelopment, synapse formation and maintenance, establishment of the blood-brain barrier, and myelination. Further, dysfunction of aGPCRs have been associated with disorders such as gliomas, depression, and epilepsy, among many others. Herein, we review generalized properties of aGPCRs, their brain-specific expression, associations with neurological and psychiatric diseases, and potential as future pharmacological targets.
关键词	receptors; G-protein-coupled; nervous system disease; mental disorders; brain; neurodevelopment; synapses
KeyWord	receptors; G-protein-coupled; nervous system disease; mental disorders; brain; neurodevelopment; synapses
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Brandon H. Lee,Christina M. Meyer,David J. Speca,Elva Díaz*. Adhesion G-Protein Coupled Receptors in Neurological and Psychiatric Disorders [J]. Journal of Psychiatry and Brain Science. 2025; 10; (6). - .

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