帕罗西汀联合心理治疗对产后抑郁症患者负面情绪及睡眠质量的影响分析
Analysis of the effects of paroxetine combined with psychotherapy on negative mood and sleep quality in patients with postpartum depression
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| DOI |
| 刊名 |
Journal of International Psychiatry
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| 年，卷(期) |
2021, 48(1) |
| 作者 |
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| 作者单位 |
安阳市妇幼保健院 ;
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| 摘要 |
【摘要】 分析产后抑郁症患者应用帕罗西汀联合心理治疗后负面情绪及睡眠质量变化。方法 将我院111例产后抑郁症患者采用随机数字表法分组，对照组55例给予心理治疗，观察组56例增加帕罗西汀联合治疗，对比两组患者治疗后抑郁情绪、神经递质水平、神经营养因子水平、睡眠质量、临床疗效及生活质量变化。结果 治疗后，观察组HAMD、PSQI评分低于对照组，SF-36评分、5-HT、BDNF水平及总有效率高于对照组（P<0.05）。结论 帕罗西汀联合心理治疗能够有效缓解产后抑郁症患者负面情绪，改善睡眠质量，提升生活质量，其机制与调节5-HT及BDNF水平有关。
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| Abstract |
[Abstract] Objective To analyze the changes of negative mood and sleep quality of paroxetine combined with psychotherapy in patients with postpartum depression. Methods 111 patients with postpartum depression in our hospital were grouped by random number table, 55 patients in the control group were given psychological treatment, and 56 patients in the observation group were treated with paroxetine. The depression, neurotransmitter levels, and nerves in the two groups were compared after treatment. Changes in nutrition factor levels, sleep quality, clinical efficacy and quality of life. Results After treatment, the HAMD and PSQI scores in the observation group were lower than those in the control group, and the SF-36 score, 5-HT, and BDNF levels and the total effective rate were higher than those in the control group (P <0.05). Conclusion Paroxetine combined with psychotherapy can effectively alleviate negative emotions, improve sleep quality, and improve quality of life in patients with postpartum depression. The mechanism is related to regulating 5-HT and BDNF levels.
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| 基金项目 |
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| 页码 |
111-114 |
徐小芳*.
帕罗西汀联合心理治疗对产后抑郁症患者负面情绪及睡眠质量的影响分析 [J].
国际精神病学杂志.
2021; 48; (1).
111 - 114.