Journal of International Psychiatry

Abstract: Objective To explore the effects of sleep quality and negative emotions on cognitive function of postmenopausal women. Methods Eighty post-menopausal women were selected as the research object, and the simple intelligent screening scale (MMSE) was used to evaluate cognitive function, and they were divided into cognitive decline group and normal cognitive group. The Pittsburgh Sleep Quality Index (PSQI) was used to evaluate sleep quality, the Depression Self-rating Scale (SDS) was used to evaluate depression status, and the Anxiety Self-rating Scale (SAS) was used to evaluate anxiety status. All subjects were drawn with fasting blood to detect ovarian hormone levels such as estradiol (E2) and testosterone (T). Results The proportion of sleep disturbance in the cognitive reduction group was 63.6%, which was significantly higher than that in the normal cognitive group (34.5%) (P <0.05); the PSQI score in the cognitive reduction group was higher than that in the normal cognitive group (P <0.05). The SAS and SDS scores of those with sleep disorders in both groups were higher than those of normal sleep (P <0.05); the SAS and SDS scores of sleep disorders and normal sleep in cognitive decline group were higher than that of normal cognitive group (P <0.05). The E2 level of sleep-disordered persons in the two groups was lower than that of normal sleepers (P <0.05); the E2 level of sleep-disordered and normal sleepers in the cognitively reduced group was lower than that in the cognitively normal group (P <0.05). Postmenopausal womens MMSE was negatively correlated with PSQI, SDS and SAS (P <0.05), and positively correlated with E2 levels (P <0.05); PSQI was positively correlated with SDS and SAS (P <0.05), was correlated with E2 levels Negative correlation (P <0.05); SDS was positively correlated with SAS (P <0.05) and negatively correlated with E2 level (P <0.05); SAS was negatively correlated with E2 level (P <0.05). Conclusion Postmenopausal womens sleep disturbances and negative emotions can affect their cognitive function, so special attention should be paid to this group of people. The reduction of E2 level may be one of the common mechanisms among the three and can be used as a clinical research direction.

Key words: Sleep quality; negative emotions; postmenopausal; cognitive function