文拉法辛对慢性乙肝合并焦虑抑郁患者负面情绪及睡眠质量的影响
Effect of Venlafaxine on Negative Emotions and Sleep Quality of Patients with Chronic Hepatitis B Complicated with Anxiety and Depression
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| DOI |
| 刊名 |
Journal of International Psychiatry
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| 年，卷(期) |
2020, 47(4) |
| 作者 |
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| 作者单位 |
河南科技大学第一附属医院 ;
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| 摘要 |
【摘要】 分析慢性乙肝合并焦虑抑郁患者应用文拉法辛治疗后效果。方法 将我院91例慢性乙肝合并焦虑抑郁患者采用随机数字表法进行分组，对照组45例给予心理治疗，观察组46例增加文拉法辛联合治疗，对比两组患者治疗后5-羟色胺（5-HT）、去甲肾上腺素、血清脑源性神经生长因子、焦虑抑郁情绪、睡眠质量及生活质量变化。结果 治疗后，观察组BDNF、NE、5-HT水平及SF-36评分高于对照组，SAS、SDS及PSQI评分低于对照组（P<0.05）。结论 文拉法辛能够有效改善慢性乙肝合并焦虑抑郁患者睡眠质量，消除负面情绪，提升患者生活质量，其机制与改善机体受体功能，促进神经元修复有关。
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| Abstract |
[Abstract] Objective To analyze the effect of venlafaxine on chronic hepatitis B patients with anxiety and depression. Methods 91 patients with chronic hepatitis B combined with anxiety and depression in our hospital were grouped by random number table method, 45 patients in the control group were given psychotherapy, and 46 patients in the observation group were treated with venlafaxine combination therapy. 5-HT), norepinephrine, serum brain-derived nerve growth factor, anxiety and depression, sleep quality and quality of life changes. Results After treatment, the BDNF, NE, 5-HT levels and SF-36 scores in the observation group were higher than those in the control group, and the SAS, SDS and PSQI scores were lower than those in the control group (P <0.05). Conclusion Venlafaxine can effectively improve the sleep quality, eliminate negative emotions and improve the quality of life of patients with chronic hepatitis B combined with anxiety and depression. The mechanism is related to improving the bodys receptor function and promoting neuron repair.
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| 基金项目 |
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| 页码 |
788-790 |
佳莉娟*.
文拉法辛对慢性乙肝合并焦虑抑郁患者负面情绪及睡眠质量的影响 [J].
国际精神病学杂志.
2020; 47; (4).
788 - 790.